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Who was studied 288 British ancestry cases, 5,102 British ancestry controls.
The effect
Each copy of the T allele carried 2.28 times the odds of Alzheimer's disease in APOE E4 homozygosity (95% confidence interval 2.01-2.55); p = 5 × 10−9.
How common The T allele had a frequency of about 7% in the people studied.
Where it sits Chromosome 1, band 1p32.2 — in an intron of DAB1.
What each result means
C/CNo copy of the version the research linked to Alzheimer's disease in APOE E4 homozygosity. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Alzheimer's disease in APOE E4 homozygosity. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alzheimer's disease in APOE E4 homozygosity. That is the strongest link of the three results. A link in a study is not a diagnosis.
Neurobiology of aging · 2022 · PMID 35977442 · open access
Questions about rs112437613
What is rs112437613?
rs112437613 is a single position in the genome, in or near the DAB1 gene. Published research associates it with alzheimer's disease in apoe e4 homozygosity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs112437613 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs112437613 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112437613 come from?
GWAS Catalog, Neurobiology of aging 2022, PMID:35977442. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Alzheimer's disease in APOE E4 homozygosity (rs112437613). MyGeneLog™. https://www.mygenelog.com/variants/rs112437613