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Waist-to-hip ratio adjusted for body mass index

MACROD1 · rs11231693

What the study found

Who was studied up to 56,910 European ancestry men, up to 86,570 European ancestry women; replicated in up to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African American/Afro-Caribbean ancestry men, 6,258 African American/Afro-Caribbean ancestry women, 2,285 South Asian ancestry men, 506 South Asian ancestry women, 195 Seychellois ancestry men, 266 Seychellois ancestry women.

The effect Each copy of the A allele shifted the measure 0.0684 higher (95% confidence interval 0.048-0.089); p = 3 × 10−11.

How common The A allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 11, band 11q13.1 — in an intron of MACROD1.

What each result means

A/A Two copies of the version the research linked to Waist-to-hip ratio adjusted for body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Waist-to-hip ratio adjusted for body mass index. That is a smaller link than two copies.
G/G No copy of the version the research linked to Waist-to-hip ratio adjusted for body mass index. This is the starting point the study compared everyone against.
Source

Questions about rs11231693

What is rs11231693?

rs11231693 is a single position in the genome, in or near the MACROD1 gene. Published research associates it with waist-to-hip ratio adjusted for body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11231693 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11231693 come from?

GWAS Catalog, Nature 2015, PMID:25673412. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Waist-to-hip ratio adjusted for body mass index (rs11231693). MyGeneLog™. https://www.mygenelog.com/variants/rs11231693

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