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Medication use (diuretics)

OR4A15 · rs11229252

Where this position leads

Condition: Medication Use as a Genetic Trait

rs11229252 Condition: Medication Use as a Genetic Trait Medication Use as a Genetic Trait Condition rs11229252 rs11229252 OR4A15

What the study found

Who was studied 34,453 European ancestry cases, 194,633 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0717 lower (95% confidence interval 0.047-0.096); p = 1 × 10−8.

How common The T allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 11, band 11q11 — between genes, 5.8 kb from OR4A15.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Medication use (diuretics) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Medication use (diuretics).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Medication use (diuretics) compared to the general population.
Source

Questions about rs11229252

What is rs11229252?

rs11229252 is a single position in the genome, in or near the OR4A15 gene. Published research associates it with medication use (diuretics). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11229252 linked to?

On MyGeneLog this position is linked to Medication Use as a Genetic Trait. The research behind each link, and its sources, are set out on that condition page.

Does having rs11229252 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11229252 come from?

GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Medication use (diuretics) (rs11229252). MyGeneLog™. https://www.mygenelog.com/variants/rs11229252

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