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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 14,296 European ancestry individuals; replicated in 5,698 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.215 lower (95% confidence interval 0.17-0.26); p = 1 × 10−23.
How common The A allele had a frequency of about 90% in the people studied.
Where it sits Chromosome 17, band 17q25.3 — in an intron of AFMID.
What each result means
A/ATwo copies of the version the research linked to N-acetylkynurenine (2) levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to N-acetylkynurenine (2) levels. That is a smaller link than two copies.
C/CNo copy of the version the research linked to N-acetylkynurenine (2) levels. This is the starting point the study compared everyone against.
Nature medicine · 2022 · PMID 36357675 · open access
Questions about rs112281307
What is rs112281307?
rs112281307 is a single position in the genome, in or near the AFMID gene. Published research associates it with n-acetylkynurenine (2) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs112281307 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112281307 come from?
GWAS Catalog, Nature medicine 2022, PMID:36357675. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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