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LTBP3 protein level (protein group normalized intensity)

near LTBP3 · rs11227226

What the study found

Who was studied 1,252 European, Hispanic or African ancestry individuals; replicated in 325 Arab, Indian or Filipino ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.746 higher (95% confidence interval 0.61-0.88); p = 4 × 10−28.

How common The T allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 11, band 11q13.1 — in a non-coding transcript of ZNRD2-DT.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of LTBP3 protein level (protein group normalized intensity) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with LTBP3 protein level (protein group normalized intensity).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of LTBP3 protein level (protein group normalized intensity) compared to the general population.
Source

Questions about rs11227226

What is rs11227226?

rs11227226 is a single position in the genome, in or near the near LTBP3 gene. Published research associates it with ltbp3 protein level (protein group normalized intensity). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11227226 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11227226 come from?

GWAS Catalog, Nature genetics 2025, PMID:41310232. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

LTBP3 protein level (protein group normalized intensity) (rs11227226). MyGeneLog™. https://www.mygenelog.com/variants/rs11227226

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