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Who was studied 37,759 European ancestry cases, 7,509 African American cases, 1,234 Latino cases, 22,778 East Asian ancestry cases, 91,590 European ancestry controls, 8,337 African American controls, 3,090 Latino controls, 35,362 East Asian ancestry controls.
The effect
Each copy of the C allele carried 1.05 times the odds of Schizophrenia (95% confidence interval 1.03-1.07); p = 1 × 10−8.
Where it sits Chromosome 11, band 11q22.3 — between genes, 82.8 kb from CASP12.
What each result means
C/CTwo copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
rs11226509 is a single position in the genome, in or near the CASP12 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11226509 linked to?
On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.
Does having rs11226509 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11226509 come from?
GWAS Catalog, Schizophrenia bulletin 2021, PMID:33169155. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 9126Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others6Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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