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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,903 European ancestry cases, 428,916 European ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 2 × 10−11.
How common The T allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 17, band 17p13.3 — in an intron of SMG6.
What each result means
C/CNo copy of the version the research linked to Mitral valve prolapse after mitral valve surgery. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Mitral valve prolapse after mitral valve surgery. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Mitral valve prolapse after mitral valve surgery. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs112258894 is a single position in the genome, in or near the SMG6 gene. Published research associates it with mitral valve prolapse after mitral valve surgery. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs112258894 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112258894 come from?
GWAS Catalog, European heart journal 2022, PMID:35245370. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Mitral valve prolapse after mitral valve surgery (rs112258894). MyGeneLog™. https://www.mygenelog.com/variants/rs112258894