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Bladder cancer

CASC15 · rs112204664

Where this position leads

Condition: Bladder Cancer

rs112204664 Condition: Bladder Cancer Bladder Cancer Condition rs112204664 rs112204664 CASC15

What the study found

Who was studied 30,156 European ancestry cases, 1,527,568 European ancestry controls.

The effect Each copy of the A allele carried 1.12 times the odds of Bladder cancer (95% confidence interval 1.09115566176294-1.14550475592139); p = 2 × 10−19.

How common The A allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 6, band 6p22.3 — in an intron of CASC15.

What each result means

A/A Two copies of the version the research linked to Bladder cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Bladder cancer. That is a smaller link than two copies.
G/G No copy of the version the research linked to Bladder cancer. This is the starting point the study compared everyone against.
Source
Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk
Prokunina-Olsson L, Florez-Vargas O, Levin MG, Dutta D, Breeze CE, Hurwitz LM, Yan W, Lamy P, Papenberg BW, Wang K, Lee CH, Milne RL
and 45 more — show all
Gu J, Um CY, Joseph V, Furberg H, Le Calvez-Kelm F, Lori A, Choudhury PP, Afshar N, Kogevinas M, Offit K, Vermeulen SH, López de Maturana E, Albanes D, Purdue MP, Cortessis VK, Karagas MR, Kooperberg C, Bjurlin M, Tadesse DA, Moore SC, Huang WY, Haiman CA, Stern MC, Eliassen AH, Mucci LA, Aben KK, Galesloot TE, Verma A, Yoshino S, Hikino K, Terao C, Rafnar T, Matsuda K, Shuin T, Garcia-Closas M, Real FX, Kiemeney LA, Chanock SJ, Malats N, Silverman DT, Dyrskjot L, Rothman N, Damrauer SM, Koutros S, Damrauer JS
UROMOL Consortium
Nature communications · 2026 · PMID 42706231 · open access

Questions about rs112204664

What is rs112204664?

rs112204664 is a single position in the genome, in or near the CASC15 gene. Published research associates it with bladder cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs112204664 linked to?

On MyGeneLog this position is linked to Bladder Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs112204664 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs112204664 come from?

GWAS Catalog, Nature communications 2026, PMID:42706231. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bladder cancer (rs112204664). MyGeneLog™. https://www.mygenelog.com/variants/rs112204664

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