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Pemphigus vulgaris

UBASH3B · rs11218708

Where this position leads

Condition: Pemphigus Vulgaris

rs11218708 Condition: Pemphigus Vulgaris Pemphigus Vulgaris Condition rs11218708 rs11218708 UBASH3B

What the study found

Who was studied 240 Han Chinese ancestry cases, 1,031 Han Chinese ancestry controls; replicated in 252 Han Chinese ancestry cases, 1,852 Han Chinese ancestry controls.

The effect Each copy of the A allele carried 1.54 times the odds of Pemphigus vulgaris; p = 3 × 10−8.

How common The A allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 11, band 11q24.1 — between genes, 12.1 kb from GLULP3.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pemphigus vulgaris compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pemphigus vulgaris.
G/G Published research associates this genotype with typical/baseline likelihood of Pemphigus vulgaris — no copies of the reported risk allele.
Source
Association Study and Fine-Mapping Major Histocompatibility Complex Analysis of Pemphigus Vulgaris in a Han Chinese Population
Gao J, Zhu C, Zhang Y, Sheng Y, Yang F, Wang W, Qian W, Chen S, Zhu Q, Zuo X, Tang H, Tang X
and 13 more — show all
Li Y, Cheng H, Zhou F, Liu S, Chen G, Zheng X, Zhu Z, Wang Z, Yang S, Luo X, Ye D, Zhang X, Sun L
The Journal of investigative dermatology · 2018 · PMID 29857070

Questions about rs11218708

What is rs11218708?

rs11218708 is a single position in the genome, in or near the UBASH3B gene. Published research associates it with pemphigus vulgaris. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11218708 linked to?

On MyGeneLog this position is linked to Pemphigus Vulgaris. The research behind each link, and its sources, are set out on that condition page.

Does having rs11218708 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11218708 come from?

GWAS Catalog, J Invest Dermatol 2018, PMID:29857070. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Pemphigus vulgaris (rs11218708). MyGeneLog™. https://www.mygenelog.com/variants/rs11218708

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