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Platelet count

DRC12 · rs11217176

Where this position leads

Condition: Blood Cell Counts

rs11217176 Condition: Blood Cell Counts Blood Cell Counts Condition rs11217176 rs11217176 DRC12

What the study found

Who was studied 542,827 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0614 SD unit higher (95% confidence interval 0.057-0.065); p = 7 × 10−194.

How common The A allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 11, band 11q23.3 — in an intron of DRC12.

What each result means

A/A Two copies of the version the research linked to Platelet count. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Platelet count. That is a smaller link than two copies.
G/G No copy of the version the research linked to Platelet count. This is the starting point the study compared everyone against.
Source

Questions about rs11217176

What is rs11217176?

rs11217176 is a single position in the genome, in or near the DRC12 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11217176 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs11217176 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11217176 come from?

GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Platelet count (rs11217176). MyGeneLog™. https://www.mygenelog.com/variants/rs11217176

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