Gene Knowledge Graph
UTC
Sensitive

Rheumatoid arthritis (ACPA-positive)

DDX6 · rs11217037

Where this position leads

Condition: Rheumatoid Arthritis

rs11217037 Condition: Rheumatoid Arthritis Rheumatoid Arthritis Condition rs11217037 rs11217037 DDX6

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Rheumatoid arthritis (ACPA-positive) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Rheumatoid arthritis (ACPA-positive).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Rheumatoid arthritis (ACPA-positive) compared to the general population.
Source
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci
Kim K, Bang SY, Lee HS, Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Kang YM, Kim SK, Suh CH
and 30 more — show all
Shim SC, Lee SS, Lee J, Chung WT, Choe JY, Shin HD, Lee JY, Han BG, Nath SK, Eyre S, Bowes J, Pappas DA, Kremer JM, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Ärlestig L, Okada Y, Diogo D, Liao KP, Karlson EW, Raychaudhuri S, Rantapää-Dahlqvist S, Martin J, Klareskog L, Padyukov L, Gregersen PK, Worthington J, Greenberg JD, Plenge RM, Bae SC
Annals of the rheumatic diseases · 2015 · PMID 24532676

Questions about rs11217037

What is rs11217037?

rs11217037 is a single position in the genome, in or near the DDX6 gene. Published research associates it with rheumatoid arthritis (acpa-positive). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11217037 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11217037 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11217037 come from?

GWAS Catalog, Ann Rheum Dis 2014, PMID:24532676. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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