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HDL cholesterol

SIK3 · rs11216230

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs11216230 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs11216230 rs11216230 SIK3

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of HDL cholesterol compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with HDL cholesterol.
G/G Published research associates this genotype with typical/baseline likelihood of HDL cholesterol — no copies of the reported risk allele.
Source
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos
Ko A, Cantor RM, Weissglas-Volkov D, Nikkola E, Reddy PM, Sinsheimer JS, Pasaniuc B, Brown R, Alvarez M, Rodriguez A, Rodriguez-Guillen R, Bautista IC
and 19 more — show all
Arellano-Campos O, Muñoz-Hernández LL, Salomaa V, Kaprio J, Jula A, Jauhiainen M, Heliövaara M, Raitakari O, Lehtimäki T, Eriksson JG, Perola M, Lohmueller KE, Matikainen N, Taskinen MR, Rodriguez-Torres M, Riba L, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P
Nature communications · 2014 · PMID 24886709 · open access

Questions about rs11216230

What is rs11216230?

rs11216230 is a single position in the genome, in or near the SIK3 gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11216230 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs11216230 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11216230 come from?

GWAS Catalog, Nat Commun 2014, PMID:24886709. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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