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Who was studied 3,701 Mexican ancestry individuals; replicated in 5,114 Mexican ancestry individuals, 903 Mexican ancestry individuals from 73 dyslipidemic families.
The effect
Each copy of the A allele shifted the measure 0.22 higher; p = 3 × 10−10.
Where it sits Chromosome 11, band 11q23.3 — in an intron of SIK3.
What each result means
A/ATwo copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
G/GNo copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
Nature communications · 2014 · PMID 24886709 · open access
Questions about rs11216230
What is rs11216230?
rs11216230 is a single position in the genome, in or near the SIK3 gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11216230 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs11216230 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11216230 come from?
GWAS Catalog, Nat Commun 2014, PMID:24886709. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 333219123210Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity1Meta AI9Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others10Total33Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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