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Waist-hip ratio

SIK3 · rs11216183

Where this position leads

Condition: Waist-to-Hip Ratio (Body Fat Distribution)

rs11216183 Condition: Waist-to-Hip Ratio (Body Fat Distribution) Waist-to-Hip Ratio (Body Fat Distri… Condition rs11216183 rs11216183 SIK3

What the study found

Who was studied 697,734 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0226 higher (95% confidence interval 0.016-0.029); p = 3 × 10−11.

How common The A allele had a frequency of about 9% in the people studied.

Where it sits Chromosome 11, band 11q23.3 — in an intron of SIK3.

What each result means

A/A Two copies of the version the research linked to Waist-hip ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Waist-hip ratio. That is a smaller link than two copies.
C/C No copy of the version the research linked to Waist-hip ratio. This is the starting point the study compared everyone against.
Source

Questions about rs11216183

What is rs11216183?

rs11216183 is a single position in the genome, in or near the SIK3 gene. Published research associates it with waist-hip ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11216183 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.

Does having rs11216183 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11216183 come from?

GWAS Catalog, Human molecular genetics 2019, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Waist-hip ratio (rs11216183). MyGeneLog™. https://www.mygenelog.com/variants/rs11216183

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