Standard

Mean corpuscular hemoglobin

HBA1 · rs112128183

Where this position leads

Condition: Blood Cell Counts

rs112128183 Condition: Blood Cell Counts Blood Cell Counts Condition rs112128183 rs112128183 HBA1

What the study found

Who was studied 172,332 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.059 lower (95% confidence interval 0.043-0.075); p = 2 × 10−12.

How common The C allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 16, band 16p13.3 — between genes, 0.4 kb from HBA1.

What each result means

C/C Two copies of the version the research linked to Mean corpuscular hemoglobin. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Mean corpuscular hemoglobin. That is a smaller link than two copies.
G/G No copy of the version the research linked to Mean corpuscular hemoglobin. This is the starting point the study compared everyone against.
Source

Questions about rs112128183

What is rs112128183?

rs112128183 is a single position in the genome, in or near the HBA1 gene. Published research associates it with mean corpuscular hemoglobin. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs112128183 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs112128183 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs112128183 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Mean corpuscular hemoglobin (rs112128183). MyGeneLog™. https://www.mygenelog.com/variants/rs112128183

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