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Asthma

CARD11 · rs112119265

Where this position leads

Condition: Asthma

What the study found

Who was studied 56,167 White-British ancestry cases, 352,255 White-British ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0778 lower (95% confidence interval 0.051-0.105); p = 2 × 10⁻⁸.

How common The G allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 7, band 7p22.2 — in an intron of CARD11.

What each result means

G/G Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Asthma. That is a smaller link than two copies.

T/T No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.

Source

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank

Valette K, Li Z, Bon-Baret V, Chignon A, Bérubé JC, Eslami A, Lamothe J, Gaudreault N, Joubert P, Obeidat M, van den Berge M, Timens W

and 11 more — show all

Sin DD, Nickle DC, Hao K, Labbé C, Godbout K, Côté A, Laviolette M, Boulet LP, Mathieu P, Thériault S, Bossé Y

Communications biology · 2021 · PMID 34103634 · open access

Questions about rs112119265

What is rs112119265?

rs112119265 is a single position in the genome, in or near the CARD11 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs112119265 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs112119265 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs112119265 come from?

GWAS Catalog, Communications biology 2021, PMID:34103634. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs112119265). MyGeneLog™. https://www.mygenelog.com/variants/rs112119265

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