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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 61,745 African ancestry individuals, 6,967 Asian ancestry individuals, 297,166 European ancestry individuals, 26,644 Hispanic or Latin American individuals.
The effect
Each copy of the T allele shifted the measure 0.14 higher (95% confidence interval 0.12-0.16); p = 1 × 10−32.
Where it sits Chromosome 19, band 19q13.33 — in an intron of TMEM277P.
What each result means
C/CNo copy of the version the research linked to Prostate-specific antigen levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Prostate-specific antigen levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Prostate-specific antigen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39930085 · open access
Questions about rs112091145
What is rs112091145?
rs112091145 is a single position in the genome, in or near the TMEM277P gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs112091145 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112091145 come from?
GWAS Catalog, Nature genetics 2025, PMID:39930085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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