LEPR · rs11208722
Where this position leads
Condition: C-Reactive Protein Levels
Strength of the evidence
Its strongest genetic-study result is p = 10−35, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 65,000 individuals (C-reactive protein), 96,598 individuals (triglycerides).
The effect The reported allele is A; the catalogue records no effect size ; p = 8 × 10−36.
Where it sits Chromosome 1, band 1p31.3 — between genes, 55.7 kb from RN7SL854P.
rs11208722 is a single position in the genome, in or near the LEPR gene. Published research associates it with c-reactive protein levels or triglyceride levels (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, BMC Genomics 2016, PMID:27286809. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
C-reactive protein levels or triglyceride levels (pleiotropy) (rs11208722). MyGeneLog™. https://www.mygenelog.com/variants/rs11208722