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Who was studied 252,438 European ancestry cases, 1,959,739 European ancestry controls, 9,826 East Asian ancestry cases, 140,446 East Asian ancestry controls, 754 South Asian ancestry cases, 52,054 South Asian ancestry controls, 9,485 African ancestry cases, 109,006 African ancestry controls, 3,447 Admixed American ancestry cases, 46,818 Admixed American ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0231 lower (95% confidence interval 0.016-0.03); p = 5 × 10−11.
How common The A allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 10, band 10q26.11 — between genes, 7.8 kb from CACUL1.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40645996 · open access
Questions about rs11198553
What is rs11198553?
rs11198553 is a single position in the genome, in or near the near CACUL1 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11198553 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs11198553 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11198553 come from?
GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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