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diastolic blood pressure (DBP, mean, inv-normal transformed)

near VPS25 · rs111982267

Where this position leads

Condition: Blood Pressure

rs111982267 Condition: Blood Pressure Blood Pressure Condition rs111982267 rs111982267 near VPS25

What the study found

Who was studied 119,332 African American or Afro-Caribbean individuals, 57,990 Hispanic or Latin American individuals, 6,421 East Asian ancestry individuals, 425,743 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0353 lower (95% confidence interval 0.026-0.044); p = 3 × 10−14.

How common The G allele had a frequency of about 90% in the people studied.

Where it sits Chromosome 17, band 17q21.2 — between genes, 2.2 kb from VPS25.

What each result means

G/G Two copies of the version the research linked to diastolic blood pressure (DBP, mean, inv-normal transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to diastolic blood pressure (DBP, mean, inv-normal transformed). That is a smaller link than two copies.
T/T No copy of the version the research linked to diastolic blood pressure (DBP, mean, inv-normal transformed). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs111982267

What is rs111982267?

rs111982267 is a single position in the genome, in or near the near VPS25 gene. Published research associates it with diastolic blood pressure (dbp, mean, inv-normal transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs111982267 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs111982267 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs111982267 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

diastolic blood pressure (DBP, mean, inv-normal transformed) (rs111982267). MyGeneLog™. https://www.mygenelog.com/variants/rs111982267

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