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Ulcerative colitis

NKX2-3 · rs11190140

Where this position leads

Condition: Ulcerative Colitis

rs11190140 Condition: Ulcerative Colitis Ulcerative Colitis Condition rs11190140 rs11190140 NKX2-3

What the study found

Who was studied 2,693 European ancestry cases, 6,791 European ancestry controls; replicated in 2,009 European ancestry cases, 1,580 European ancestry controls.

The effect Each copy of the T allele carried 1.23 times the odds of Ulcerative colitis; p = 1 × 10−8.

Where it sits Chromosome 10, band 10q24.2 — inside LINC01475.

What each result means

C/C No copy of the version the research linked to Ulcerative colitis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Ulcerative colitis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Ulcerative colitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11190140

What is rs11190140?

rs11190140 is a single position in the genome, in or near the NKX2-3 gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11190140 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11190140 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11190140 come from?

GWAS Catalog, Nat Genet 2010, PMID:20228799. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ulcerative colitis (rs11190140). MyGeneLog™. https://www.mygenelog.com/variants/rs11190140

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