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Who was studied 4,442 European ancestry cases, 1,104,335 European ancestry controls; replicated in 725 cases, 164,346 controls.
The effect
Each copy of the C allele carried 1.20 times the odds of Chronic lymphocytic leukemia (95% confidence interval 1.15-1.24); p = 2 × 10−18.
How common The C allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 10, band 10q23.33 — between genes, 31.9 kb from Y_RNA.
What each result means
C/CTwo copies of the version the research linked to Chronic lymphocytic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Chronic lymphocytic leukemia. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Chronic lymphocytic leukemia. This is the starting point the study compared everyone against.
Blood cancer journal · 2025 · PMID 40883272 · open access
Questions about rs11187157
What is rs11187157?
rs11187157 is a single position in the genome, in or near the near HHEX gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11187157 linked to?
On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.
Does having rs11187157 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11187157 come from?
GWAS Catalog, Blood cancer journal 2025, PMID:40883272. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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