Standard
Corrected insulin response
HHEX · rs11187144
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied up to 4,961 European individuals, up to 411 Old Order Amish (founder/genetic isolate) individuals; replicated in 20,722 European individuals.
The effect
Each copy of the T allele shifted the measure 0.12 lower (95% confidence interval 0.079-0.161); p = 3 × 10−8.
Where it sits Chromosome 10, band 10q23.33 — between genes, 0.3 kb from Y_RNA.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Corrected insulin response — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Corrected insulin response.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Corrected insulin response compared to the general population.
Source
A central role for GRB10 in regulation of islet function in man
Prokopenko I,
Poon W,
Mägi R,
Prasad B R,
Salehi SA,
Almgren P,
Osmark P,
Bouatia-Naji N,
Wierup N,
Fall T,
Stančáková A,
Barker A
and 53 more — show all
Lagou V,
Osmond C,
Xie W,
Lahti J,
Jackson AU,
Cheng YC,
Liu J,
O'Connell JR,
Blomstedt PA,
Fadista J,
Fadista J,
Alkayyali S,
Dayeh T,
Ahlqvist E,
Taneera J,
Lecoeur C,
Kumar A,
Hansson O,
Hansson K,
Voight BF,
Kang HM,
Levy-Marchal C,
Vatin V,
Palotie A,
Syvänen AC,
Mari A,
Weedon MN,
Loos RJ,
Ong KK,
Nilsson P,
Isomaa B,
Tuomi T,
Wareham NJ,
Stumvoll M,
Widen E,
Lakka TA,
Langenberg C,
Tönjes A,
Rauramaa R,
Kuusisto J,
Frayling TM,
Froguel P,
Walker M,
Eriksson JG,
Ling C,
Kovacs P,
Ingelsson E,
McCarthy MI,
Shuldiner AR,
Silver KD,
Laakso M,
Groop L,
Lyssenko V
PLoS genetics · 2014 · PMID 24699409 · open access
Questions about rs11187144
What is rs11187144?
rs11187144 is a single position in the genome, in or near the HHEX gene. Published research associates it with corrected insulin response. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs11187144 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11187144 come from?
GWAS Catalog, PLoS Genet 2014, PMID:24699409. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants