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High density lipoprotein cholesterol levels

near PCIF1 · rs111859808

What the study found

Who was studied 146,492 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0744 lower (95% confidence interval 0.057-0.091); p = 5 × 10−16.

How common The A allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 20, band 20q13.12 — between genes, 4.5 kb from PCIF1.

What each result means

A/A Two copies of the version the research linked to High density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to High density lipoprotein cholesterol levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to High density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
Source

Questions about rs111859808

What is rs111859808?

rs111859808 is a single position in the genome, in or near the near PCIF1 gene. Published research associates it with high density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs111859808 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs111859808 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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High density lipoprotein cholesterol levels (rs111859808). MyGeneLog™. https://www.mygenelog.com/variants/rs111859808

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