Standard

Body mass index

NTNG1 · rs11185092

Where this position leads

What the study found

Who was studied up to 72,390 Japanese ancestry women, up to 85,894 Japanese ancestry men; replicated in up to 10,048 Japanese ancestry women, up to 5,098 Japanese ancestry men, up to 181,999 European ancestry women, up to 140,155 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.019 higher (95% confidence interval 0.013-0.025); p = 3 × 10⁻⁸.

How common The G allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 1, band 1p13.3 — in an intron of NTNG1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.

Source

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T

and 10 more — show all

Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M, Kamatani Y

Nature genetics · 2017 · PMID 28892062

Questions about rs11185092

What is rs11185092?

rs11185092 is a single position in the genome, in or near the NTNG1 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11185092 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs11185092 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11185092 come from?

GWAS Catalog, Nature genetics 2017, PMID:28892062. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs11185092). MyGeneLog™. https://www.mygenelog.com/variants/rs11185092

← See all variants