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Circulating levels of total-tau

near IL15 · rs111836296

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 953 African American individuals.

The effect Each copy of the T allele shifted the measure 0.54 lower (95% confidence interval 0.34-0.74); p = 2 × 10−8.

How common The T allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 4, band 4q31.21 — between genes, 5.8 kb from IL15.

What each result means

C/C No copy of the version the research linked to Circulating levels of total-tau. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Circulating levels of total-tau. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Circulating levels of total-tau. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels
Sarnowski C, Ghanbari M, Bis JC, Logue M, Fornage M, Mishra A, Ahmad S, Beiser AS, Boerwinkle E, Bouteloup V, Chouraki V, Cupples LA
and 24 more — show all
Damotte V, DeCarli CS, DeStefano AL, Djoussé L, Fohner AE, Franz CE, Kautz TF, Lambert JC, Lyons MJ, Mosley TH, Mukamal KJ, Pase MP, Portilla Fernandez EC, Rissman RA, Satizabal CL, Vasan RS, Yaqub A, Debette S, Dufouil C, Launer LJ, Kremen WS, Longstreth WT, Ikram MA, Seshadri S
Communications biology · 2022 · PMID 35396452 · open access

Questions about rs111836296

What is rs111836296?

rs111836296 is a single position in the genome, in or near the near IL15 gene. Published research associates it with circulating levels of total-tau. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs111836296 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs111836296 come from?

GWAS Catalog, Communications biology 2022, PMID:35396452. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Circulating levels of total-tau (rs111836296). MyGeneLog™. https://www.mygenelog.com/variants/rs111836296

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