Standard

Nicotine metabolite ratio in current smokers

EGLN2 · rs111825958

What the study found

Who was studied 954 African American individuals; replicated in 480 African American individuals.

The effect Each copy of the A allele shifted the measure 0.71 lower (95% confidence interval 0.58-0.84); p = 6 × 10−26.

Where it sits Chromosome 19, band 19q13.2 — in an intron of CYP2F2P.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Nicotine metabolite ratio in current smokers compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Nicotine metabolite ratio in current smokers.
C/C Published research associates this genotype with typical/baseline likelihood of Nicotine metabolite ratio in current smokers — no copies of the reported risk allele.
Source

Questions about rs111825958

What is rs111825958?

rs111825958 is a single position in the genome, in or near the EGLN2 gene. Published research associates it with nicotine metabolite ratio in current smokers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs111825958 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs111825958 come from?

GWAS Catalog, Addiction 2017, PMID:28921760. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Nicotine metabolite ratio in current smokers (rs111825958). MyGeneLog™. https://www.mygenelog.com/variants/rs111825958

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