Standard

Externalizing behaviour (multivariate analysis)

near LINC01479 · rs11176927

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied up to 53,293 European ancestry Attention-deficit/hyperactivity disorder individuals, up to 164,684 European ancestry problematic alcohol use individuals, up to 186,875 European ancestry lifetime cannabis use individuals, up to 357,187 European ancestry individuals measuring reverse-coded age at first sexual intercourse, up to 336,121 European ancestry individuals measuring number of sexual partners, up to 426,379 European ancestry individuals measuring general risk tolerance, up to 1,251,809 European ancestry individuals measuring lifetime smoking initiation.

The effect Each copy of the C allele shifted the measure 0.007 higher (95% confidence interval 0.005-0.009); p = 3 × 10⁻¹⁰.

How common The C allele had a frequency of about 51% in the people studied.

Where it sits Chromosome 12, band 12q15 — between genes, 35.5 kb from LINC01479.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Externalizing behaviour (multivariate analysis) compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Externalizing behaviour (multivariate analysis).

T/T Published research associates this genotype with typical/baseline likelihood of Externalizing behaviour (multivariate analysis) — no copies of the reported risk allele.

Source

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M

and 17 more — show all

Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM

COGA Collaborators

Nature neuroscience · 2021 · PMID 34446935 · open access

Questions about rs11176927

What is rs11176927?

rs11176927 is a single position in the genome, in or near the near LINC01479 gene. Published research associates it with externalizing behaviour (multivariate analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11176927 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11176927 come from?

GWAS Catalog, Nature neuroscience 2021, PMID:34446935. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Externalizing behaviour (multivariate analysis) (rs11176927). MyGeneLog™. https://www.mygenelog.com/variants/rs11176927

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