Sensitive

Differentiated thyroid cancer

MSRB3 · rs11175834

Where this position leads

What the study found

Who was studied 470 Korean ancestry cases, 8,279 Korean ancestry controls; replicated in 615 Korean ancestry cases, 605 Korean ancestry controls.

The effect Each copy of the T allele carried 1.37 times the odds of Differentiated thyroid cancer; p = 4 × 10⁻⁸.

How common The T allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 12, band 12q14.3 — in an intron of LINC02454.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Differentiated thyroid cancer — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Differentiated thyroid cancer.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Differentiated thyroid cancer compared to the general population.

Source

Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer

Son HY, Hwangbo Y, Yoo SK, Im SW, Yang SD, Kwak SJ, Park MS, Kwak SH, Cho SW, Ryu JS, Kim J, Jung YS

and 10 more — show all

Kim TH, Kim SJ, Lee KE, Park DJ, Cho NH, Sung J, Seo JS, Lee EK, Park YJ, Kim JI

Nature communications · 2017 · PMID 28703219 · open access

Questions about rs11175834

What is rs11175834?

rs11175834 is a single position in the genome, in or near the MSRB3 gene. Published research associates it with differentiated thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11175834 linked to?

On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs11175834 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11175834 come from?

GWAS Catalog, Nat Commun 2017, PMID:28703219. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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