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Who was studied 9,433 British ancestry cases, 318,237 British ancestry controls.
The effect
Each copy of the C allele carried 1.10 times the odds of Asthma (childhood onset) (95% confidence interval 1.063-1.137); p = 3 × 10−8.
How common The C allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — in an intron of TRIM26.
What each result means
C/CTwo copies of the version the research linked to Asthma (childhood onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Asthma (childhood onset). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Asthma (childhood onset). This is the starting point the study compared everyone against.
The Lancet. Respiratory medicine · 2019 · PMID 31036433
Questions about rs1117490
What is rs1117490?
rs1117490 is a single position in the genome, in or near the TRIM26 gene. Published research associates it with asthma (childhood onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1117490 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs1117490 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1117490 come from?
GWAS Catalog, The Lancet. Respiratory medicine 2019, PMID:31036433. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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