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Allergic rhinitis

AQP5 · rs11169225

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Allergic rhinitis compared to the general population.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Allergic rhinitis.

T/T Published research associates this genotype with typical/baseline likelihood of Allergic rhinitis — no copies of the reported risk allele.

Source

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS

and 76 more — show all

Antó JM, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt CEM, Bleecker ER, Bonàs-Guarch S, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Dmitrieva J, Duijts L, Ege MJ, Gauderman WJ, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Jónsdóttir I, Kabesch M, Kaprio J, Kumar A, Lee YA, Levin AM, Li X, Lorenzo-Diaz F, Melén E, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pershagen G, Pino-Yanes M, Probst-Hensch NM, Rüschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Bønnelykke K

23andMe Research Team · AAGC collaborators

Nature genetics · 2018 · PMID 30013184

Questions about rs11169225

What is rs11169225?

rs11169225 is a single position in the genome, in or near the AQP5 gene. Published research associates it with allergic rhinitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11169225 linked to?

On MyGeneLog this position is linked to Allergic Rhinitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11169225 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11169225 come from?

GWAS Catalog, Nat Genet 2018, PMID:30013184. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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