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Who was studied 12,924 European ancestry cases, 21,442 European ancestry controls; replicated in 25,683 European ancestry cases, 17,015 European ancestry controls.
The effect
Each copy of the C allele carried 1.05 times the odds of Inflammatory bowel disease (95% confidence interval 1.024-1.084); p = 8 × 10−9.
How common The C allele had a frequency of about 47% in the people studied.
Where it sits Chromosome 12, band 12q13.11 — in an intron of HDAC7.
What each result means
C/CTwo copies of the version the research linked to Inflammatory bowel disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Inflammatory bowel disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Inflammatory bowel disease. This is the starting point the study compared everyone against.
rs11168249 is a single position in the genome, in or near the VDR gene. Published research associates it with inflammatory bowel disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11168249 linked to?
On MyGeneLog this position is linked to Inflammatory Bowel Disease, Chronic Rhinosinusitis with Nasal Polyps. The research behind each link, and its sources, are set out on that condition page.
Does having rs11168249 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11168249 come from?
GWAS Catalog, Nature 2012, PMID:23128233. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 415214122123Reads by AI crawlersClaude5ChatGPT2Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others23Total41Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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