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Pulmonary function

HTR4 · rs11168048

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

rs11168048 Condition: Pulmonary Function (Lung Capacity) Pulmonary Function (Lung Capacity) Condition rs11168048 rs11168048 HTR4

What the study found

Who was studied 20,890 European ancestry individuals; replicated in 16,178 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.4 % lower; p = 1 × 10−11.

How common The T allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 5, band 5q32 — in an intron of LOC107986462.

What each result means

C/C No copy of the version the research linked to Pulmonary function. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Pulmonary function. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Pulmonary function. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11168048

What is rs11168048?

rs11168048 is a single position in the genome, in or near the HTR4 gene. Published research associates it with pulmonary function. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11168048 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

Does having rs11168048 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11168048 come from?

GWAS Catalog, Nat Genet 2009, PMID:20010835. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulmonary function (rs11168048). MyGeneLog™. https://www.mygenelog.com/variants/rs11168048

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