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Obstructive sleep apnea trait (apnea hypopnea index)

DENND4C · rs111654000

What the study found

Who was studied 1,942 African American individuals.

The effect Each copy of the A allele shifted the measure 11.9 lower (95% confidence interval 7.73-16.15); p = 3 × 10−8.

Where it sits Chromosome 9, band 9p22.1 — in an intron of DENND4C.

What each result means

A/A Two copies of the version the research linked to Obstructive sleep apnea trait (apnea hypopnea index). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Obstructive sleep apnea trait (apnea hypopnea index). That is a smaller link than two copies.
C/C No copy of the version the research linked to Obstructive sleep apnea trait (apnea hypopnea index). This is the starting point the study compared everyone against.
Source

Questions about rs111654000

What is rs111654000?

rs111654000 is a single position in the genome, in or near the DENND4C gene. Published research associates it with obstructive sleep apnea trait (apnea hypopnea index). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs111654000 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs111654000 come from?

GWAS Catalog, Genome medicine 2021, PMID:34446064. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Obstructive sleep apnea trait (apnea hypopnea index) (rs111654000). MyGeneLog™. https://www.mygenelog.com/variants/rs111654000

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