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Who was studied 296,021 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 5.47 z-score higher; p = 5 × 10−8.
How common The C allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 6, band 6q22.1 — between genes, 56.9 kb from VGLL2.
What each result means
C/CTwo copies of the version the research linked to Atrial fibrillation (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Atrial fibrillation (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Atrial fibrillation (MTAG). This is the starting point the study compared everyone against.
NPJ genomic medicine · 2025 · PMID 41022758 · open access
Questions about rs11153653
What is rs11153653?
rs11153653 is a single position in the genome, in or near the near VGLL2 gene. Published research associates it with atrial fibrillation (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11153653 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs11153653 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11153653 come from?
GWAS Catalog, NPJ genomic medicine 2025, PMID:41022758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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