Who was studied 344,104 European ancestry individuals, 150,266 East Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0409 lower (95% confidence interval 0.035-0.047); p = 2 × 10−40.
Where it sits Chromosome 5, band 5q11.2 — in an intron of ARL15.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Serum creatinine levels — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum creatinine levels.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum creatinine levels compared to the general population.
rs111366116 is a single position in the genome, in or near the ARL15 gene. Published research associates it with serum creatinine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs111366116 linked to?
On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.
Does having rs111366116 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs111366116 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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