Urine S-1-pyrroline-5-carboxylate levels in chronic kidney disease
PYCR3 · rs11136305
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,179 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.091 lower (95% confidence interval 0.066-0.116); p = 3 × 10−12.
How common The T allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 8, band 8q24.3 — in an intron of PYCR3.
What each result means
C/CNo copy of the version the research linked to Urine S-1-pyrroline-5-carboxylate levels in chronic kidney disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Urine S-1-pyrroline-5-carboxylate levels in chronic kidney disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Urine S-1-pyrroline-5-carboxylate levels in chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2023 · PMID 37277652 · open access
Questions about rs11136305
What is rs11136305?
rs11136305 is a single position in the genome, in or near the PYCR3 gene. Published research associates it with urine s-1-pyrroline-5-carboxylate levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs11136305 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11136305 come from?
GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Urine S-1-pyrroline-5-carboxylate levels in chronic kidney disease (rs11136305). MyGeneLog™. https://www.mygenelog.com/variants/rs11136305