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Aortic stenosis

near PDGFRA · rs11133315

Where this position leads

What the study found

Who was studied 45,352 European ancestry cases, 1,938,877 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0343 lower (95% confidence interval 0.025-0.044); p = 4 × 10⁻¹³.

How common The G allele had a frequency of about 82% in the people studied.

Where it sits Chromosome 4, band 4q12 — between genes, 5.1 kb from RPL22P13.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Aortic stenosis — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Aortic stenosis.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Aortic stenosis compared to the general population.

Source

Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk

Kany S, Rämö JT, Hou C, Jurgens SJ, Khurshid S, Nauffal V, Cunningham JW, Lau ES, Koyama S, Ho JE, Olgin JE, Elmariah S

and 4 more — show all

Palotie A, Lindsay ME, Ellinor PT, Pirruccello JP

FinnGen

Nature genetics · 2026 · PMID 41419685 · open access

Questions about rs11133315

What is rs11133315?

rs11133315 is a single position in the genome, in or near the near PDGFRA gene. Published research associates it with aortic stenosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11133315 linked to?

On MyGeneLog this position is linked to Aortic Stenosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11133315 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11133315 come from?

GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Aortic stenosis (rs11133315). MyGeneLog™. https://www.mygenelog.com/variants/rs11133315

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