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Neuroticism

RNF103-CHMP3 · rs11127043

Where this position leads

Condition: Neuroticism

rs11127043 Condition: Neuroticism Neuroticism Condition rs11127043 rs11127043 RNF103-CHMP3

What the study found

Who was studied 449,484 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 5.78 z score higher (95% confidence interval -); p = 8 × 10−9.

Where it sits Chromosome 2, band 2p11.2 — in an intron of RNF103-CHMP3.

What each result means

C/C No copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11127043

What is rs11127043?

rs11127043 is a single position in the genome, in or near the RNF103-CHMP3 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11127043 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs11127043 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11127043 come from?

GWAS Catalog, Nat Genet 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs11127043). MyGeneLog™. https://www.mygenelog.com/variants/rs11127043

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