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Revision surgery after total joint arthroplasty

CAMTA1 · rs11120968

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 94 cases from twins, 1,036 controls from twins.

The effect Each copy of the A allele carried 2.34 times the odds of Revision surgery after total joint arthroplasty (95% confidence interval 1.74-3.13); p = 1 × 10−8.

How common The A allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 1, band 1p36.23 — in an intron of CAMTA1.

How common each version is

AG
Korean KRGDB
A 30.2% · G 69.8%
Korean Korea4K
A 29.0% · G 71.0%
Korean Korea1K
A 27.8% · G 72.2%
Japanese ToMMo
A 27.6% · G 72.4%
Vietnamese
A 21.3% · G 78.7%
World gnomAD
A 36.1% · G 63.9%
World 1000 Genomes
A 33.7% · G 66.3%
World TOPMed
A 35.8% · G 64.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Revision surgery after total joint arthroplasty. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Revision surgery after total joint arthroplasty. That is a smaller link than two copies.
G/G No copy of the version the research linked to Revision surgery after total joint arthroplasty. This is the starting point the study compared everyone against.
Source
Risk of Revision After Arthroplasty Associated with Specific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 Twins Treated with Arthroplasty
Brüggemann A, Brüggemann A, Eriksson N, Michaëlsson K, Hailer NP
The Journal of bone and joint surgery. American volume · 2022 · PMID 34982741

Quoting this page

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Revision surgery after total joint arthroplasty (rs11120968). MyGeneLog™. https://www.mygenelog.com/variants/rs11120968

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