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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 576 European ancestry cases, 2,223 European ancestry controls, 1,050 Hispanic or Latin American cases, 1,828 Hispanic or Latin American controls, 367 African ancestry cases, 729 African ancestry controls, 147 Asian ancestry cases, 126 Asian ancestry controls, 2 cases, 8 controls; replicated in 607 European ancestry cases, 1,685 European ancestry controls.
The effect
Each copy of the G allele carried 1.81 times the odds of Orofacial clefts (95% confidence interval 1.57-2.07); p = 3 × 10−17.
Where it sits Chromosome 1, band 1q32.2 — in an intron of TRAF3IP3.
What each result means
A/ANo copy of the version the research linked to Orofacial clefts. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Orofacial clefts. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Orofacial clefts. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs11119345 is a single position in the genome, in or near the TRAF3IP3 gene. Published research associates it with orofacial clefts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs11119345 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11119345 come from?
GWAS Catalog, Human molecular genetics 2016, PMID:27033726. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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