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Who was studied 34,930 East Asian ancestry individuals, 187,167 European ancestry individuals; replicated in 8,741 Chinese ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.071 lower (95% confidence interval 0.047-0.095); p = 3 × 10−9.
How common The T allele had a frequency of about 87% in the people studied.
Where it sits Chromosome 16, band 16q22.1 — in the 3′ untranslated region of LCAT.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-08-30.
ClinVar record 1221653NM_005072.5(SLC12A4):c.*1361A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to HDL cholesterol levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to HDL cholesterol levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to HDL cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1109166 is a single position in the genome, in or near the LCAT gene. Published research associates it with hdl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1109166 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs1109166 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1109166 come from?
GWAS Catalog, Hum Mol Genet 2017, PMID:28334899. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 25191239Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI9Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others9Total25Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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