ZMIZ1 · rs1108617
Where this position leads
Condition: Psoriasis
Strength of the evidence
Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 11,024 European ancestry psoriasis cases, 74,124 European ancestry diabetes cases, 840,342 European ancestry controls.
The effect Each copy of the A allele carried 1.07 times the odds of Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect) (95% confidence interval -); p = 3 × 10−11.
Where it sits Chromosome 10, band 10q22.3 — in an intron of ZMIZ1.
How common each version is
AG
A 29.1% · G 70.9%
A 29.4% · G 70.6%
A 29.3% · G 70.7%
A 37.1% · G 62.9%
A 43.5% · G 56.5%
A 52.0% · G 48.0%
A 47.4% · G 52.6%
A 52.2% · G 47.8%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs1108617 is a single position in the genome, in or near the ZMIZ1 gene. Published research associates it with psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, J Invest Dermatol 2020, PMID:33385400. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect) (rs1108617). MyGeneLog™. https://www.mygenelog.com/variants/rs1108617