Sensitive

Parkinson's disease

TBC1D5 · rs1108439

Where this position leads

Condition: Parkinson's Disease

rs1108439 Condition: Parkinson's Disease Parkinson's Disease Condition rs1108439 rs1108439 TBC1D5

What the study found

Who was studied 57,893 European ancestry cases, 1,505,102 European ancestry controls, 7,046 East Asian ancestry cases, 176,756 East Asian ancestry controls, 2,440 Hispanic or Latin American cases, 582,220 Hispanic or Latin American controls, 288 African ancestry cases, 193,985 African ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10−8.

Where it sits Chromosome 3, band 3p24.3 — inside TBC1D5.

What each result means

A/A Two copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.
Source

Questions about rs1108439

What is rs1108439?

rs1108439 is a single position in the genome, in or near the TBC1D5 gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1108439 linked to?

On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs1108439 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1108439 come from?

GWAS Catalog, Nature genetics 2024, PMID:38155330. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Parkinson's disease (rs1108439). MyGeneLog™. https://www.mygenelog.com/variants/rs1108439

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