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Periodontitis

SIGLEC5 · rs11084095

Where this position leads

What the study found

Who was studied 4,102 European ancestry cases, 8,489 European ancestry controls; replicated in 993 European ancestry cases, 1,419 European ancestry controls.

The effect Each copy of the A allele carried 1.17 times the odds of Periodontitis (95% confidence interval 1.11-1.24); p = 5 × 10⁻⁸.

How common The A allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 19, band 19q13.41 — in an intron of SIGLEC5.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Periodontitis compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Periodontitis.

G/G Published research associates this genotype with typical/baseline likelihood of Periodontitis — no copies of the reported risk allele.

Source

Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci

Munz M, Richter GM, Loos BG, Jepsen S, Divaris K, Offenbacher S, Teumer A, Holtfreter B, Kocher T, Bruckmann C, Jockel-Schneider Y, Graetz C

and 15 more — show all

Ahmad I, Staufenbiel I, van der Velde N, Uitterlinden AG, de Groot LCPGM, Wellmann J, Berger K, Krone B, Hoffmann P, Laudes M, Lieb W, Franke A, Erdmann J, Dommisch H, Schaefer AS

European journal of human genetics : EJHG · 2019 · PMID 30218097

Questions about rs11084095

What is rs11084095?

rs11084095 is a single position in the genome, in or near the SIGLEC5 gene. Published research associates it with periodontitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11084095 linked to?

On MyGeneLog this position is linked to Periodontitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11084095 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11084095 come from?

GWAS Catalog, Eur J Hum Genet 2018, PMID:30218097. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Periodontitis (rs11084095). MyGeneLog™. https://www.mygenelog.com/variants/rs11084095

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