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Who was studied 34,658 European American cases, 167,346 European American controls, 17,267 African American cases, 39,381 African American controls, 3,449 Latino American cases, 10,726 Latino American controls, 164 East Asian American cases, 1,210 East Asian American controls, 46 South Asian American cases, 144 South Asian American controls.
The effect
Each copy of the T allele carried 1.06 times the odds of Alcohol use disorder (95% confidence interval 1.04-1.07); p = 2 × 10−10.
How common The T allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 16, band 16q12.2 — in an intron of FTO.
What each result means
C/CNo copy of the version the research linked to Alcohol use disorder. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Alcohol use disorder. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alcohol use disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 30940813 · open access
Questions about rs11075992
What is rs11075992?
rs11075992 is a single position in the genome, in or near the FTO gene. Published research associates it with alcohol use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11075992 linked to?
On MyGeneLog this position is linked to Alcohol Use Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs11075992 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11075992 come from?
GWAS Catalog, Nature communications 2019, PMID:30940813. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 141247Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)4ByteDance (Doubao)4Others7Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alcohol use disorder (rs11075992). MyGeneLog™. https://www.mygenelog.com/variants/rs11075992