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Body mass index

GGNBP2 · rs1106908

Where this position leads

Conditions: Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight

rs1106908 Condition: Waist-to-Hip Ratio (Body Fat Distribution) Waist-to-Hip Ratio (Body Fat Distri… Condition Condition: Obesity and Body Weight Obesity and Body Weight Condition rs1106908 rs1106908 GGNBP2

What the study found

Who was studied 806,834 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0161 lower (95% confidence interval 0.013-0.019); p = 8 × 10−23.

How common The A allele had a frequency of about 45% in the people studied.

Where it sits Chromosome 17, band 17q12 — a synonymous change in GGNBP2.

What ClinVar records

Classification Benign for GGNBP2-related disorder; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2019-10-30. ClinVar record 3059591 NM_024835.5(GGNBP2):c.1608G>A (p.Lys536=)

What this is ClinVar's aggregate record for this position (as of its 2026-10-05 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
G/G Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
Source
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, Yang J, Jones S
and 10 more — show all
Beaumont R, Croteau-Chonka DC, Winkler TW, Hattersley AT, Loos RJF, Hirschhorn JN, Visscher PM, Frayling TM, Yaghootkar H, Lindgren CM
GIANT Consortium
Human molecular genetics · 2019 · PMID 30239722 · open access

Questions about rs1106908

What is rs1106908?

rs1106908 is a single position in the genome, in or near the GGNBP2 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1106908 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs1106908 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1106908 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs1106908). MyGeneLog™. https://www.mygenelog.com/variants/rs1106908

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