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Brain age gap derived from gray matter

TRIM47 · rs1105917

What the study found

Who was studied 54,890 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.226 years higher (95% confidence interval 0.17-0.28); p = 8 × 10−15.

How common The T allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 17, band 17q25.1 — in a non-coding transcript of TRIM47.

What each result means

C/C No copy of the version the research linked to Brain age gap derived from gray matter. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Brain age gap derived from gray matter. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Brain age gap derived from gray matter. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1105917

What is rs1105917?

rs1105917 is a single position in the genome, in or near the TRIM47 gene. Published research associates it with brain age gap derived from gray matter. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1105917 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1105917 come from?

GWAS Catalog, Nature aging 2025, PMID:41044200. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Brain age gap derived from gray matter (rs1105917). MyGeneLog™. https://www.mygenelog.com/variants/rs1105917

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