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Triglyceride levels

ZNF664 · rs11057408

Where this position leads

What the study found

Who was studied 28,183 East Asian ancestry individuals, 177,861 European ancestry individuals; replicated in 10,857 Chinese ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0258 lower (95% confidence interval 0.019-0.033); p = 2 × 10⁻¹¹.

How common The T allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 12, band 12q24.31 — in an intron of RFLNA.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Triglyceride levels — no copies of the reported risk allele.

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Triglyceride levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Triglyceride levels compared to the general population.

Source

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, Long J, Wu Y, Wang YX, Takeuchi F, Wu JY, Jung KJ

and 103 more — show all

Hu C, Akiyama K, Zhang Y, Moon S, Johnson TA, Li H, Dorajoo R, He M, Cannon ME, Roman TS, Salfati E, Lin KH, Guo X, Sheu WHH, Absher D, Adair LS, Assimes TL, Aung T, Cai Q, Chang LC, Chen CH, Chien LH, Chuang LM, Chuang SC, Du S, Fan Q, Fann CSJ, Feranil AB, Friedlander Y, Gordon-Larsen P, Gu D, Gui L, Guo Z, Heng CK, Hixson J, Hou X, Hsiung CA, Hu Y, Hwang MY, Hwu CM, Isono M, Juang JJ, Khor CC, Kim YK, Koh WP, Kubo M, Lee IT, Lee SJ, Lee WJ, Liang KW, Lim B, Lim SH, Liu J, Nabika T, Pan WH, Peng H, Quertermous T, Sabanayagam C, Sandow K, Shi J, Sun L, Tan PC, Tan SP, Taylor KD, Teo YY, Toh SA, Tsunoda T, van Dam RM, Wang A, Wang F, Wang J, Wei WB, Xiang YB, Yao J, Yuan JM, Zhang R, Zhao W, Chen YI, Rich SS, Rotter JI, Wang TD, Wu T, Lin X, Han BG, Tanaka T, Cho YS, Katsuya T, Jia W, Jee SH, Chen YT, Kato N, Jonas JB, Cheng CY, Shu XO, He J, Zheng W, Zheng W, Wong TY, Huang W, Kim BJ, Tai ES, Mohlke KL, Sim X

Human molecular genetics · 2017 · PMID 28334899

Questions about rs11057408

What is rs11057408?

rs11057408 is a single position in the genome, in or near the ZNF664 gene. Published research associates it with triglyceride levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11057408 linked to?

On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.

Does having rs11057408 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11057408 come from?

GWAS Catalog, Hum Mol Genet 2017, PMID:28334899. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Triglyceride levels (rs11057408). MyGeneLog™. https://www.mygenelog.com/variants/rs11057408

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