Who was studied 29,212 European ancestry cases, 400,539 European ancestry controls, 4,150 East Asian ancestry cases, 155,540 East Asian ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.115 lower (95% confidence interval 0.088-0.141); p = 4 × 10−17.
Where it sits Chromosome 12, band 12p12.1 — between genes, 25 kb from KNOP1P1.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Atrial fibrillation/atrial flutter — no copies of the reported risk allele.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Atrial fibrillation/atrial flutter.
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Atrial fibrillation/atrial flutter compared to the general population.
rs11047527 is a single position in the genome, in or near the near KNOP1P1 gene. Published research associates it with atrial fibrillation/atrial flutter. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11047527 linked to?
On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.
Does having rs11047527 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11047527 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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