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Sensitive

eGFR in type 1 diabetes kidney disease cases (minimal adjustment)

near KIAA1549L · rs11032245

Where this position leads

Condition: Type 1 Diabetes

rs11032245 Condition: Type 1 Diabetes Type 1 Diabetes Condition rs11032245 rs11032245 near KIAA154…

What the study found

Who was studied 4,608 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 1.94 higher (95% confidence interval 1.27-2.62); p = 2 × 10−8.

How common The T allele had a frequency of about 99% in the people studied.

Where it sits Chromosome 11, band 11p13 — between genes, 4.3 kb from KIAA1549L.

What each result means

C/C No copy of the version the research linked to eGFR in type 1 diabetes kidney disease cases (minimal adjustment). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to eGFR in type 1 diabetes kidney disease cases (minimal adjustment). That is a smaller link than two copies.
T/T Two copies of the version the research linked to eGFR in type 1 diabetes kidney disease cases (minimal adjustment). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci
Cole JB, Dahlström EH, Fermin D, Gupta Y, Hill C, Smyth LJ, Liu H, Kreienkamp RJ, Kreienkamp RJ, Pezzolesi MG, Cao JJ, Valo E
and 44 more — show all
Valo E, Chen WM, Onengut-Gumuscu S, Rich SS, Brennan EP, Andrews D, Kennedy C, Gu HF, Stechemesser L, Weitgasser R, Sokolovska J, Radzeviciene L, Verkauskiene R, Panduru NM, Rossing P, Ahluwalia TS, Zerbini G, Marre M, Hadjadj S, Costacou T, Miller RG, Klein BE, Lee KE, Snell-Bergeon JK, Caramori ML, Mauer M, Brismar K, Bjornstad P, McKnight AJ, McKnight AJ, McKay G, Nair V, Salem RM, Groop PH, Godson C, Susztak K, Kretzler M, Maxwell AP, Krolewski A, Paterson A, Paterson A, Sandholm-Lafferre N, Florez JC, Hirschhorn JN
Journal of the American Society of Nephrology : JASN · 2025 · PMID 40323663

Questions about rs11032245

What is rs11032245?

rs11032245 is a single position in the genome, in or near the near KIAA1549L gene. Published research associates it with egfr in type 1 diabetes kidney disease cases (minimal adjustment). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11032245 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs11032245 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11032245 come from?

GWAS Catalog, Journal of the American Society of Nephrology : JASN 2025, PMID:40323663. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

eGFR in type 1 diabetes kidney disease cases (minimal adjustment) (rs11032245). MyGeneLog™. https://www.mygenelog.com/variants/rs11032245

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